Macrophages create the elusive spermatogonial stem cell niche

(Phys.org)—Every organ strikes its own balance between self-renewal and differentiation. At one extreme is the brain, where only a few isolated outposts are known to contribute to a largely quiescent population. At another extreme are the testes, where at least in males, prolific germline turnover is maintained amidst a protracted and deliberate multi-month creation cycle. Perhaps surprisingly, both organs are uniquely immunoprivileged against various vascular indiscretions and yet rely on various myeloid-derived cells like macrophages or microglia to instruct important structural maturations. googletag.cmd.push(function() { googletag.display(‘div-gpt-ad-1449240174198-2′); }); The so-called stem cell ‘niche’ is the microenvironment of the stem cell: all those physical and molecular intangibles that nourish, shield and inform its major life decisions. In creatures like worms and flies a well-defined stem cell niche is distally localized within a polarized gonad. By contrast, each testes of the mammal can contain up to 40,000 potential stem cell niches more-or-less randomly dispersed among its seminiferous tubules. A recent paper published in Cell Reports h...

Expert talks and other event on the calendar in Greenwich

Greenwich Commissioner of Public Works Amy Siebert will speak Wednesday before the Greenwich Retired Men’s Association in a free program at the First Presbyterian Church, 1 W. Putnam Ave. Social time starts at 10:40 a.m., followed by the speaker at 11 a.m. She will speak on “Greenwich Public Works: What Does the Future Hold?” Greenwich Commissioner of Public Works Amy Siebert will speak Wednesday before the Greenwich Retired Men’s Association in a free program at the First Presbyterian Church, 1 W. Putnam Ave. Social time starts Greenwich Commissioner of Public Works Amy Siebert will speak Wednesday before the Greenwich Retired Men’s Association in a free program at the First Presbyterian Church, 1 W. Putnam Ave. Social time starts at 10:40 a.m., followed by the speaker at 11 a.m. She will speak on “Greenwich Public Works: What Does the Future Hold?” Greenwich Commissioner of Public Works Amy Siebert will speak Wednesday before the Greenwich Retired Men’s Association in a free program at the First Presbyterian Church, 1 W. Putnam Ave. Social time starts For the latest events and activities happening in Greenwich, turn to For the record. To have your event included, submit a des...

Glass Tubing & Rods Marché Mondial 2020 – SCHOTT AG, Pegasus Glass, Richland Glass, VitroCom, Cansci Glass Products

La société fournit une analyse détaillée du marché et des aspects futurs du marché Tubes et tiges en verre. L’analyse se concentre sur des données critiques et importantes, ce qui fait de cette recherche un outil très important pour les experts, les analystes et les gestionnaires pour obtenir une analyse immédiate. Le Rapport fournit une analyse qui inclus les prévisions de développement de la taille du marché Tubes et tiges en verre de 2018-2025. Le Rapport contient des informations complètes sur les principaux acteurs du marché Tubes et tiges en verre à travers le monde. En outre, il fournit leur part de marché par diverses régions, avec l’introduction de l’entreprise et du produit, et sa position sur le marché Tubes et tiges en verre. De plus, le Rapport tient compte de leurs stratégies de marketing ainsi que des développements clés récents ainsi que de l’aperçu général de l’entreprise. En plus de cela, le Rapport intègre les facteurs moteurs de la croissance du marché et les contraintes de ce marché. Nos meilleurs analystes ont examiné le Rapport de marché avec la référence des stocks et des données fournies par les acteurs clés: SCHOTT AG Pegasus Glass Richland Glass VitroC...

Solar PV eBOS Buyer’s Guide 2020 | Solar Builder Solar PV eBOS Buyer’s Guide 2020

We asked wire management and electrical component providers to tell us about their latest and greatest products (inverters will be broken out into their own Buyer’s Guide next month). Trends in eBOS components right now include AC combiners, above ground cable management and heavy-duty clamps. Check them all out below. Solar Snake Max is Snake Tray’s new patented cable management system for utility grade installations. The easy snap together components maintain NEC 310.15 code compliant cable separation. Construction cycle times and material costs will substantially decrease with this new innovative approach to managing high voltage cables. The CAB Solar Cable Management System utilizes hangers suspended from messenger wire to carry cabling in grid-scale solar fields. There are both a standard system, which uses galvanized messenger wire, and a patented integrated grounding system that utilizes a copper composite messenger wire which has the ability to be used as an ECG and GEC. There is an engineering evaluation on the grounding capabilities to make sure it matches your system’s needs, and the system is listed by ETL to UL 2703. What’s cool? CAB’s integrated grounding system is...

It’s going to last all week! Worst snow for 18 years brings Britain slithering to a halt… and costs economy £3bn

By Beth Hale for the Daily Mail and Lucy Ballinger for MailOnline Updated: 01:29 GMT, 3 February 2009 The heaviest snowfall in 18 years brought the nation to a standstill, crippling businesses, transport networks, hospitals and schools – and further hammering the recession-hit economy. Snow-go zone: A hopeful commuter does her best to dig out her car in Chiswick, West London, yesterday And those who did struggle in were angry that their journey was made even harder because transport planners appeared woefully unprepared – despite the Met Office having issued extreme weather warnings as long ago as Thursday. Yesterday morning London’s buses were halted for the first time in living memory – they even continued to run during the Blitz – and the rail network ground to a predictable halt. Airports were closed and Heathrow, the world’s busiest terminal, was forced to close both its runways for several hours. There was severe disruption at Gatwick, London City airport, Luton, Southampton, Leeds, Newcastle, Birmingham and Manchester. The problems could get worse with more snow expected overnight and today, and the prospect of temperatures plummeting ...

Interview with Chair Lynne Ensor at Microbiology Boston Conference, speaks about Coronavirus -

SMi Reports: Lynne Ensor, Vice President, Technical, Parexel International discussed the latest development in the field, her thoughts on the developing regulatory environment and more. The 3rd Annual Pharmaceutical Microbiology East Coast Conference will convene in Boston on April 29th and 30th, 2020 to address the unique needs of pharmaceutical microbiologists and interdisciplinary scientists involved in manufacturing. It will also provide excellent opportunities to network, interact, exchange, as well as learn from industry experts and professionals from around the world. SMi Group caught up with the conference chair Lynne Ensor, Vice President, Technical, Parexel International, to find out more about her expertise and role in the industry, what she’s looking forward to at this year’s Microbiology East Coast Conference, what vital topic she’ll be addressing in her presentation, and much more. In particular, Lynne provided a thorough overview of significant developments within the field from over the past year, including a discussion on the new Corona Virus. The pharmaceutical microbiology market has matured greatly over recent years, what significant developments have you no...

Cell Culture Dishes Market [ PDF ] latest demand by 2020-2024 with leading players like

“Ongoing Trends of Cell Culture Dishes Market :- Petri dish is a type of glass or plastic shallow round dish with a close fitting lid which is a vital tool in scientific laboratories. The uses for this piece of equipment are varied, but it is most well-known for holding a culture medium upon which cells, bacteria, and viruses can be grown and studied. Most major scientific breakthroughs have been greatly assisted by the use of petri dishes whether they involve the structure of a virus or the ability to clone meat. The Cell Culture Dishes market industry report highlights the important components related to the top sellers of Cell Culture Dishes industry that influence the market. The study incorporates industry esteem chain, powerful business strategies, cost, structure, creation limit, conveyance, market range and limits usage rate. Cell Culture Dishes market provides basic information of market members and organizing profiling, contact data, item/benefit beds, income development, revenue generation, and gross deals. Access PDF Sample Copy of the Report, With 30 mins free consultation! Click [email protected] https://www.garnerinsights.com/Global-Cell-Culture-Dishes-Market-2019...

Answer Man: ‘Monstrosity of a pole’ in South Asheville?

Readers ask about a huge new telecommunications tower going up along Hendersonville Road in South Asheville. Welcome to our new and improved comments, which are for subscribers only. This is a test to see whether we can improve the experience for you. You do not need a Facebook profile to participate. You will need to register before adding a comment. Typed comments will be lost if you are not logged in. Please be polite. It’s OK to disagree with someone’s ideas, but personal attacks, insults, threats, hate speech, advocating violence and other violations can result in a ban. If you see comments in violation of our community guidelines, please report them. This 95-foot “concealed monopole” for cellular communications recently was installed on Hendersonville Road in South Asheville. (Photo: John Boyle/jboyle@citizentimes.com) Question: Someone has probably already asked about this, but I am curious what this monstrosity of a pole is going up behind “Ballard’s Appliance” on Hendersonville Road? It’s much bigger than “normal” cellphone towers and billboard columns.  Real answer: Let’s face it — cellphone towers generally are not known for their beauty...

Techron® Marine Fuel System Treatment Now Featured in All West Marine Stores Nationwide

SAN RAMON, Calif., Feb. 25, 2020 /PRNewswire/ – Chevron Products Company, a division of Chevron U.S.A. Inc. and a leading provider of premium aftermarket fuel additives, engine oils, lubricants, coolants and related products, announced today that its Techron® Marine Fuel System Treatment is now available on West Marine’s website (www.westmarine.com) and will be available at all West Marine retail outlets coast-to-coast beginning April 2020. Since the product debuted in August 2018, Techron Marine has generated strong grassroots interest among boaters and fishermen. It was quickly adopted by high profile professional fishing guides, charter captains, tournament anglers and others who depend on their boats and motors to make a living. Chevron furthered this groundswell of public interest through the sponsorship of major events and tournament series, including the Texas Bass Champs Series and title sponsorship of the 2019 Techron TX Shootout, California’s 2019 Salt Water Bass Association (SWBA) Series and the internationally-attended 2019 U.S. Open Bass Tournament. It was also selected for a Top Product Award from Boating Industry magazine. With Techron Marine av...

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JavaScript seems to be disabled in your browser. You must have JavaScript enabled in your browser to utilize the functionality of this website. One of the most frequently searched terms on Truth In Aging is matrixyl 3000. This antioxidant is made by combining two peptides, palmitoyl oligopeptide and palmitoyl tetrapepide-7. It outperforms Vitamin C (and unlike some of the Cs, it doesn’t irritate) by stimulating the matrix molecules – collagens 1,3, 4 and fibronectin to reduce the appearance of wrinkles. According to clinical trials, matrixyl 3000 led to a 33% decrease in wrinkle density, a 23% decrease in the volume of wrinkles and a 20% decrease in the depth of wrinkles. One of the most frequently searched terms on Truth In Aging is matrixyl 3000. This antioxidant is made by combining two peptides, palmitoyl oligopeptide and palmitoyl tetrapepide-7. It outperforms Vitamin C (and unlike some of the Cs, it doesn’t irritate) by stimulating the matrix molecules – collagens 1,3, 4 and fibronectin to reduce the appearance of wrinkles. According to clinical trials, matrixyl 3000 led to a 33% decrease in wrinkle density, a 23% decrease in the volume of wrinkles ...

Backpack Travel Bag Market 2020 by Growth Drivers, Demand Overview, Regional Outlook, Manufacturers, Future Forecast by 2025

Global Travel bag market is also fuelled of the increase in the count of rail and road travelers, including increasing frequency of flyers. Robust and high quality international travel and immigration, functionality, improvements in product design, and upscaling affluence of middle class population in emerging nations are other major driving factors of the backpack travel bag market growth. The growing globalization has led to an increase in the sales of consumer products sector of the emerging economies and products like Travel bags and accessories. Backpack Travel Bag is a cloth sack carried on one’s back and secured with two straps that go over the shoulders, but there can be variations to this basic design that is used in travel. The manufacturers are concentrating on manufacturing lightweight and ultra-lightweight travel luggage with hard side material, as the number of Flyers have increased in the past few years. The airlines have some strict regulations about luggage, the travelers are very keen on travelling light. Global Backpack Travel Bag Market trends is segmented into several classifications including product analysis, end user/applications analysis, and regional an...

The field of Augmentative and Alternative Communciation (AAC) covers communication methods used by those who are

The field of Augmentative and Alternative Communciation (AAC) covers communication methods used by those who are unable to otherwise produce or comprehend spoken or written language. Many will be familiar with the speech synthesizer used by Stephen Hawking as just one such example of AAC technology. [Christina Hunger] is a speech language pathologist, and is intimately familiar with such tools. She decided to use these techniques to teach her dog, Stella, to talk. [Christina] began her project by implementing a button board which triggers various speech samples when triggered. There are plenty of typical words that a dog may wish to use, like beach, park, and ball – as well as words describing concepts, such as where, later, and come. Over time, she has observed Stella using the button board in various ways, that she claims indicate a deeper understanding and use of language than would normally be ascribed to a dog. From the outset, [Christina] has been intentional in her methods, being sure to only demonstrate the use of the board to Stella, rather than simply pressing the buttons for her. The experiment has many similarities to the case of Koko the gorilla, known for learning ...

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